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Nano-emulsions may boost beta-carotene availability from supplements

Researchers from the Department of Food Science, University of Massachusetts, Amherst (USA) report that excipient nanoemulsions formulated from long chain triglycerides (LCT) could significantly boost the bioaccessiblity of the carotenoid. The results were published in the Journal of Agricultural and Food Chemistry.
Excipient nanoemulsions were formulated from long or medium chain triglycerides (LCT or MCT) to determine the impact of lipid type on carotenoid bioaccessibility. Dietary supplements were tested using the GIT model in the absence or presence of excipient nanoemulsions. β-carotene bioaccessibility from tablets (0.3%) or soft gels (2.4%) was low when tested in isolation. LCT nanoemulsions greatly improved β-carotene bioaccessibility from tablets (20%) and slightly improved it from soft gels (5%), whereas MCT nanoemulsions only slightly improved bioaccessibility. These results were attributed to the ability of large carotenoid molecules to be incorporated into large mixed micelles formed by LCT digestion but not by small ones formed by MCT digestion.
The results indicate that excipient nanoemulsions have considerable potential for improving nutraceutical bioavailability from dietary supplements.

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