PARTNERS

Celery and artichokes kill human pancreatic cancer cells

Researchers from the University of Illinois, USA, discovered that apigenin and luteolin flavonoids contained in celery and artichokes kill human pancreatic cancer cells by inhibiting an important enzyme.

The objectives of this study, published on Food and Chemical Toxicology, Vol. 60, October 2013, p 83–91, were to assess the potential of dietary flavonoids apigenin (Api) and luteolin (Lut) to enhance the anti-proliferative effects of chemotherapeutic drugs on BxPC-3 human pancreatic cancer cells and to investigate the potential molecular mechanism of action.

Simultaneous treatment or pretreatment (0, 6, 24 and 42 h) of flavonoids and chemotherapeutic drugs at various concentrations (050 μM) were assessed using the MTS cell proliferation assay. Simultaneous treatment with either flavonoid (13, 25 or 50 μM) and chemotherapeutic drugs 5-fluorouracil (5-FU, 50 μM) or gemcitabine (Gem, 10 μM) for 60 h resulted in mostly less-than-additive effects (p < 0.05). Pretreatment for 24 h with 13 μM of either Api or Lut, followed by Gem for 36 h was optimal to inhibit cell proliferation. Pretreatment of cells with 1119 μM of either flavonoid for 24 h resulted in 5973% growth inhibition when followed by Gem (10 μM, 36 h). Lut (15 μM, 24 h) pretreatment followed by Gem (10 μM, 36 h), significantly decreased protein expression of nuclear GSK-3β and NF-κB p65 and increased pro-apoptotic cytosolic cytochrome c. Pretreatment of BxPC-3 human pancreatic cancer cells with low concentrations of Api or Lut effectively aid in the anti-proliferative activity of chemotherapeutic drugs.

LATEST NEWS

Effect of rosehip flour on the properties of wheat dough and bread

  Bulgarian Researchers investigated the effect of rosehip flour on some properties of wheat dough and bread, and the results were published in the Ukrainian...

Non-chlorine detergent formulations as an alternative for unpasteurised milk removal from stainless steel surfaces

  Hygiene is a major concern in the dairy industry, and detergents based on hypochlorite have commonly been utilised for cleaning-in-place (CIP) regimes. However, due...

Black soybean cooking water powder as a novel clean-label ingredient

  Black soybean cooking water (BSCW), a by-product of the soybean paste industry, is a novel foaming and emulsifying material. Its application, however, is limited...

ASCOLTATE IL PODCAST DI "ALIMENTI FUNZIONALI"

DOVE TROVARE LE NOSTRE RIVISTE

8-12/09/2024, RIMINI
24-26/09/2024 - NORIMBERGA, GERMANIA
9-12/10/2024 - MILANO
16-17/10/2024 - VERONA
17/10/2024, BERGAMO
28-31/10/2024, SHANGHAI, CINA
4-7/11/2024, PARIS, FRANCIA
5-7/11/2024 - DUBAI, EAU
6-7/11/2024 LA ROCHELLE, FRANCIA
12-15/11/2024 MILANO
18-20/11/2024 - SAHANGHAI, CINA
19-21/11/2024 - FRANCOFORTE, GERMANIA
20-21/11/2024, MILANO
24-26/11/2024 - NORIMBERGA, GERMANIA
26-28/11/2024 BORDEAUX, FRANCIA
18-22/01/2025 - RIMINI
2-5/02/2025 - COLONIA, GERMANIA
5-7/02/2025 - BERLIN, GERMANIA
16-18/02/2025 - RIMINI
23-25/02/2025 - BOLOGNA
16-18/03/2025 - DÜSSELDORF, GERMANIA
13-15/04/2025 RIYADH, ARABIA
24-26/04/2025 - ISTANBUL, TURCHIA
5-8/05/2025
13-15/05/2025 PARMA
18-22/05/2025 - DÜSSELDORF, GERMANIA
20-22/05/2025 - BARCELONA, SPAGNA
27-30/05/2025 - MILANO

CATALOGO LIBRI

CATALOGO RIVISTE