PARTNERS

Identified molecular link between gut bacteria and intestinal health

The development and severity of inflammatory bowel diseases and other chronic inflammatory conditions can be influenced by host genetic and environmental factors, including signals derived from commensal bacteria1, 2, 3, 4, 56. However, the mechanisms that integrate these diverse cues remain undefined. 
Researchers from the University of Pennsylvania (USA) discovered that the enzyme HDAC3 as a key mediator in maintaining proper intestinal integrity and function in the presence of friendly bacteria. They demonstrated that mice with an intestinal epithelial cell (IEC)-specific deletion of the epigenome-modifying enzyme histone deacetylase 3 (HDAC3ΔIEC mice) exhibited extensive dysregulation of IEC-intrinsic gene expression, including decreased basal expression of genes associated with antimicrobial defence. Critically, conventionally housed HDAC3ΔIEC mice demonstrated loss of Paneth cells, impaired IEC function and alterations in the composition of intestinal commensal bacteria. In addition, HDAC3ΔIEC mice showed significantly increased susceptibility to intestinal damage and inflammation, indicating that epithelial expression of HDAC3 has a central role in maintaining intestinal homeostasis. Re-derivation of HDAC3ΔIEC mice into germ-free conditions revealed that dysregulated IEC gene expression, Paneth cell homeostasis and intestinal barrier function were largely restored in the absence of commensal bacteria.
Although the specific mechanisms through which IEC-intrinsic HDAC3 expression regulates these complex phenotypes remain to be determined, these data indicate that HDAC3 is a critical factor that integrates commensal-bacteria-derived signals to calibrate epithelial cell responses required to establish normal host–commensal relationships and maintain intestinal homeostasis.
This research was published on Nature.

LATEST NEWS

Intense pulsed light treatment for fruits for convenience infant foods

  A Korean study aimed to assess the effects of intense pulsed light (IPL) treatment for the inactivation of Bacillus cereus spores in apples and pears for...

The influence of hot-air mechanical drying on the sensory quality of coffee

  The main aim of this Colombian study published in AIMS Agriculture and Food journal was to evaluate the impact of mechanical drying on the...

The summer issue of “Alimenti Funzionali” is now available

  In this issue, we feature the latest trend news for good health and wellness. We investigate the psycho-biology of eating behavior and we focus...

ASCOLTATE IL PODCAST DI "ALIMENTI FUNZIONALI"

DOVE TROVARE LE NOSTRE RIVISTE

8-12/09/2024, RIMINI
24-26/09/2024 - NORIMBERGA, GERMANIA
9-12/10/2024 - MILANO
16-17/10/2024 - VERONA
5-7/11/2024 - DUBAI, EAU
6-7/11/2024 LA ROCHELLE, FRANCIA
12-15/11/2024 MILANO
18-20/11/2024 - SAHANGHAI, CINA
19-21/11/2024 - FRANCOFORTE, GERMANIA
24-26/11/2024 - NORIMBERGA, GERMANIA
26-28/11/2024 BORDEAUX, FRANCIA
18-22/01/2025 - RIMINI
2-5/02/2025 - COLONIA, GERMANIA
5-7/02/2025 - BERLIN, GERMANIA
16-18/02/2025 - RIMINI
23-25/02/2025 - BOLOGNA
16-18/03/2025 - DÜSSELDORF, GERMANIA
5-8/05/2025
24-26/04/2025 - ISTANBUL, TURCHIA
13-15/05/2025 PARMA
18-22/05/2025 - DÜSSELDORF, GERMANIA
20-22/05/2025 - BARCELONA, SPAGNA
27-30/05/2025 - MILANO

CATALOGO LIBRI

CATALOGO RIVISTE